反応 #52471

反応方程式

4-bromo-3-tert-butylphenol

Intermediate 104

4-bromo-3-tert-butylphenol

imidazole

chloro-triisopropylsilane

→

title compound

(4-Bromo-3-tert-butyl-phenoxy)-triisopropyl-silane

溶媒

H2O

DMF

反応条件

後処理

1. 1
   抽出extracted with EtOAc
2. 2
   洗浄The combined organic layers were washed with H2O and saturated aqueous NaCl
3. 3
   乾燥before being dried (MgSO4)
4. 4
   濃縮concentrated under reduced pressure

実験手順

To a solution of 4-bromo-3-tert-butylphenol (Intermediate 104, 1.17 g, 5.10 mmols) and imidazole (520.0 mg, 7.65 mmols) in 10 mL DMF was added chloro-triisopropylsilane (1.18 g, 6.10 mmols). After stirring overnight at room temperature the solution was diluted with H2O and extracted with EtOAc. The combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound, 1.80 g (92%), was isolated by column chromatography (0-1.5% EtOAc—hexanes) as a colorless oil.

出典