反応 #52453

反応方程式

1-ethynyl-4-(1-benzyloxycyclopropyl)-3-ethyl-benzene

Intermediate 90

1-ethynyl-4-(1-benzyloxycyclopropyl)-3-ethyl-benzene

methyl-(4-iodophenyl)-acetate

4-iodo phenyl acetic acid methyl ester

Reagent B

4-iodo phenyl acetic acid methyl ester

→

title compound

収率 79.0%

Methyl{4-[4-(1-benzyloxycyclopropyl)-3-ethyl-phenylethynyl]-phenyl}-acetate

収率 79.0%

溶媒

triethylamine

反応条件

後処理

1. 1
   その他sparged with argon for 5 minutes

実験手順

Using General Procedure F; 1-ethynyl-4-(1-benzyloxycyclopropyl)-3-ethyl-benzene (Intermediate 90, 107.0 mg, 0.39 mmol) and methyl-(4-iodophenyl)-acetate (Reagent B, 110.0 mg, 0.39 mmol) in triethylamine (5 mL) was treated with copper(I)iodide (25.0 mg, 0.13 mmol) and sparged with argon for 5 minutes. Dichlorobis(triphenylphosphine)palladium(II) (91 mg, 0.13 mmol) was added and the reaction mixture was stirred overnight at room temperature. Column chromatography (2-4% EtOAc—hexanes) afforded 130.0 mg (79%) of the title compound as a pale-yellow oil.

出典