反応 #52416

反応方程式

[4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane

Intermediate 60

[4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane

potassium carbonate

→

1-Ethynyl-4-(1-methoxycyclopropyl)-benzene

溶媒

methanol

反応条件

実験手順

Using General Procedure E; [4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane (Intermediate 60, 285.0 mg, 1.18 mmols) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (220 mg, 100%) was used directly in the next reaction.

出典