反応 #52368

反応方程式

6-ethynyl-2,2,4,4-tetramethylchroman

tetrahydrofuran

Reagent C

2-fluoro-4-iodo phenyl acetic acid ethyl ester

triethyl amine

ethyl-2-fluoro-4-iodo phenyl acetate

2-fluoro-4-iodo phenyl acetic acid ethyl ester

→

title compound

[2-Fluoro-4-(2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)phenyl] acetic acid ethyl ester

溶媒

hexane

ethyl acetate

反応条件

実験手順

Following general procedure F and using 6-ethynyl-2,2,4,4-tetramethylchroman (0.204 g, 0.95 mmol), ethyl-2-fluoro-4-iodo phenyl acetate (Reagent C, 0.263 g, 0.86 mmol), triethyl amine, tetrahydrofuran, copper(I)iodide (0.025 g, 0.13 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.075 g, 0.11 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent, the title compound was obtained (0.21 g, 62%).

出典