反応 #52308

反応方程式

Sodium thiomethoxide

3,5-dibromopyridine

→

title compound

収率 89.0%

3-Bromo-5-methylsulfanyl-pyridine

収率 89.0%

溶媒

ethyl acetate

DMF

反応条件

後処理

1. 1
   洗浄washed several times with brine
2. 2
   乾燥The extracts were dried over magnesium sulfate
3. 3
   その他the solvent was removed under reduced pressure
4. 4
   その他The crude material was chromatographed on silica (10% ethyl acetate/hexanes)

実験手順

Sodium thiomethoxide (1.6 g, 23 mmol) was added to a solution of 3,5-dibromopyridine (5 g, 21 mmol) in DMF (25 mL). After stirring overnight at room temperature, the reaction mixture was diluted with ethyl acetate and washed several times with brine. The extracts were dried over magnesium sulfate and the solvent was removed under reduced pressure. The crude material was chromatographed on silica (10% ethyl acetate/hexanes) to give the title compound (3.8 g, 89% yield) as a clear oil.

出典