反応 #52246

反応方程式

K2CO3

Maleic anhydride

ethanolamine

acetic anhydride

sodium acetate

→

Acetoxy Ethyl Maleimide

溶媒

acetone

acetic acid

反応条件

後処理

1. 1
   温度The solution was heated to 80 C
2. 2
   workup.STIRRINGstirred for 1 hour
3. 3
   抽出The product was extracted with methylene chloride
4. 4
   その他dried
5. 5
   その他The product was purified by sublimation
6. 6
   その他yielding white crystals, m.p. 76° C. (44.1 g, 13.45%)

実験手順

Maleic anhydride (172.32 g, 1.75 mol) was added to ethanolamine (107.34 g, 1.75 mol) and dissolved in 500 mL of acetone while stirring overnight in an ice bath. To the solution, 400 mL of acetic anhydride (4.23 mol) was added with sodium acetate (144 g, 1.75 mol). The solution was heated to 80 C and stirred for 1 hour. The contents were poured into ice water and the acetic acid neutralized with K2CO3. The product was extracted with methylene chloride and then dried using magnesium sulfate. The product was purified by sublimation yielding white crystals, m.p. 76° C. (44.1 g, 13.45%).

出典