反応 #52223

反応方程式

Methyl 1-acetyl-2,3-dihydroindol-3-one-6-carboxylate

trimethyl orthoformate

p-toluene sulphonic acid

→

Methyl 1-acetyl-3-methoxyindole-6-carboxylate

溶媒

methanol

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated under reduced pressure
2. 2
   workup.ADDITIONpoured into water
3. 3
   抽出extracted with chloroform
4. 4
   その他After drying
5. 5
   その他evaporation
6. 6
   その他the product was purified by prep hplc

実験手順

Methyl 1-acetyl-2,3-dihydroindol-3-one-6-carboxylate (233 mg, 1 mmol), trimethyl orthoformate (10 ml) and p-toluene sulphonic acid (20 mg) were heated under reflux for 3 h. in methanol (10 ml). The reaction mixture was concentrated under reduced pressure, poured into water and extracted with chloroform. After drying and evaporation, the product was purified by prep hplc;

出典