反応 #521971

反応方程式

carbon monoxide

chloroacetic acid methyl ester

potassium methylate

acetic acid methyl ester

methoxyacetic acid methyl ester

→

malonic acid dimethyl ester

収率 90.0%

反応条件

後処理

1. 1
   その他In a one-liter glass flask equipped with stirrer
2. 2
   その他at 70° C.

実験手順

In a one-liter glass flask equipped with stirrer, 2 dropping funnels, a reflux condenser, a glass electrode and a glass inlet tube for carbon monoxide, 108.5 g (1 mole) of chloroacetic acid methyl ester is reacted for 61/2 hours with 1 mole of potassium methylate (28.75% solution in methanol) in the presence of 10 g of Co2 (CO)8, at 70° C., 0.8 at. CO, and a pH of approximately 8.5. The processing yields 119 g of malonic acid dimethyl ester (90% yield), and small amounts of acetic acid methyl ester and methoxyacetic acid methyl ester, plus 5 g of higher-boiling substances.

出典