反応 #521787

反応方程式

(+)-1α-ethyl-1β- carboxyethyl-6-carboxy-1,2,3,4,6,7-hexahydro-12H-indolo(2,3-a)-quinolizin-5-ium perchlorate

decalin

→

title compound

収率 97.2%

(-)-1α-Ethyl-1β- carboxyethyl-1,2,3,4,6,7-hexahydro-12H-indolo(2,3-a)quinolizin-5-ium perchlorate

収率 97.2%

反応条件

後処理

1. 1
   温度After cooling the reaction mixture
2. 2
   ろ過is filtered
3. 3
   その他the solid obtained
4. 4
   洗浄is washed decalin-free with three 5-ml
5. 5
   乾燥portions of ether and is dried

実験手順

1000 mg. (2.13 mmoles) of (+)-1α-ethyl-1β- carboxyethyl-6-carboxy-1,2,3,4,6,7-hexahydro-12H-indolo(2,3-a)-quinolizin-5-ium perchlorate in 15 ml. of decalin are heated at 160° to 170° C. for 25 minutes, with stirring. The substance melts accompanied by gas evolution. After cooling the reaction mixture is filtered, the solid obtained is washed decalin-free with three 5-ml. portions of ether and is dried. 880 mg. of the title compound are obtained. Yield: 97.2% [α]D25 =-19°.

出典