反応 #5214

反応方程式

trifluoroacetic acid

trifluoromethanesulfonic acid

3-(4-methoxybenzylthio)pyrrolidin-2-one

→

title compound

3-Mercapto-2-pyrrolidinone trifluoromethanesulfonate

溶媒

anisole

反応条件

後処理

1. 1
   濃縮At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
2. 2
   その他to leave a residue, which
3. 3
   その他was purified by column chromatography through silica gel
4. 4
   洗浄eluted with a 10:1 by volume mixture of ethyl acetate and methanol

実験手順

20 ml of trifluoroacetic acid and 0.41 ml of trifluoromethanesulfonic acid were added, whilst ice-cooling, to a solution of 949 mg of 3-(4-methoxybenzylthio)pyrrolidin-2-one in 4 ml of anisole, and then the mixture was stirred at room temperature for 30 minutes. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure to leave a residue, which was purified by column chromatography through silica gel, eluted with a 10:1 by volume mixture of ethyl acetate and methanol, to give 728 mg of the title compound as an oil.

出典