反応 #52133

反応方程式

benzyl bromide

2-(2-amino-ethoxy)ethanol

potassium carbonate

water

→

1-Dibenzylamino-5-hydroxy-3-oxapentane

溶媒

EtOH

反応条件

後処理

1. 1
   温度the mixture is refluxed for 2 hours
2. 2
   その他evaporated under vacuum
3. 3
   ろ過filtered off from the salts
4. 4
   濃縮The filtrate is concentrated under vacuum
5. 5
   その他purified by flash chromatography (silica gel/mobile phase: methylene chloride/hexane/acetone: 10/5/1)

実験手順

A mixture of 50 g (475.56 mmol) of 2-(2-amino-ethoxy)ethanol and 144.6 g (1.046 mol) of potassium carbonate in 600 ml of EtOH/60 ml of water is heated to 60° C. To this mixture is added dropwise within one hour 178.95 g (1.046 mol) of benzyl bromide and then the mixture is refluxed for 2 hours, evaporated under vacuum, the residue taken up with 1 liter of methylene chloride, and filtered off from the salts. The filtrate is concentrated under vacuum and purified by flash chromatography (silica gel/mobile phase: methylene chloride/hexane/acetone: 10/5/1).

出典