反応 #521220
ord-6026291be8084c51b7e0479860c9a254
反応方程式
2,6-difluorobenzoylchloride oxime
methyl-2-butynoate
triethyl amine
→
4-methoxycarbonyl-5-methyl-3-(2,6-difluorophenyl)isoxazole
収率 61.0%
反応条件
詳細条件
See reaction.notes.procedure_details.
実験手順
In a fashion similar to that for preparation 15, 2,6-difluorobenzoylchloride oxime (1.00 g, 5.19 mmol), methyl-2-butynoate (1.01 g, 10.4 mmol), triethyl amine (0.94 ml, 6.8 mmol) in diethyl ether (3 ml), and diethyl ether (25 ml) afforded 4-methoxycarbonyl-5-methyl-3-(2,6-difluorophenyl)isoxazole (0.80 g, 61%) after purification by column chromatography (silica gel, hexanes/diethyl ether gradient).