反応 #521210

反応方程式

2-fluorobenzoylchloride oxime

methyl-2-butynoate

Et3N

→

title compound

収率 58.0%

4-Methoxycarbonyl-5-methyl-3-(2-fluorophenyl)isoxazole

収率 58.0%

溶媒

Et2O

Et2O

Et2O

反応条件

後処理

1. 1
   洗浄washed (H2O
2. 2
   乾燥brine), dried (MgSO4)
3. 3
   ろ過filtered
4. 4
   濃縮concentrated

実験手順

To a solution (0° C., N2) of 2-fluorobenzoylchloride oxime (0.50 g, 2.9 mmol) and methyl-2-butynoate (0.57 g, 5.8 mmol) in Et2O (15 ml) was added a solution of Et3N (0.52 ml) in Et2O (2 ml) over a period of 1 h followed by warming to room temperature while stirring overnight (17 h). The reaction was diluted with Et2O, washed (H2O then brine), dried (MgSO4), filtered, and concentrated. Column chromatography (silica gel, hexanes/EtOAc gradient) gave the title compound (0.39 g, 58%).

出典