反応 #520803

反応方程式

3-(methylthio)aniline

triethyl orthoformate

ethyl nitroacetate

acetic acid

triethyl orthoformate

acetic acid

→

title compound

1-(3-Methylsulfanyl-phenyl)-1H-imidazole-4-carboxylic Acid

反応条件

実験手順

Following the general method described in example 234, 3-(methylthio)aniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a grey crystalline solid. Mp. 190-192° C. (H2O/dioxane), MS: m/e=234 (M+).

出典