反応 #51970

反応方程式

4-acetamidoacetophenone

bromine

→

title compound

収率 62.5%

N-[4-(2-bromoacetyl)phenyl]acetamide

収率 62.5%

溶媒

1,4-dioxane diethyl ether

反応条件

後処理

1. 1
   ろ過The solid was collected by filtration
2. 2
   洗浄washed with diethyl ether
3. 3
   その他dried under high vacuum

実験手順

To a suspension of 4-acetamidoacetophenone (Lancaster, 5.32 g, 0.03 mol) in 1,4-dioxane/diethyl ether (100 mL, 1:2, v/v) was added bromine (1.53 mL, 0.03 mol) via a syringe. The reaction mixture was stirred at room temperature for 4 hours until the color of the mixture was changed from brown to white. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum to give the title compound as a white solid (4.8 g).

出典