反応 #5193

反応方程式

methyl fluorosulfonate

(2S, 4S)-2-carbamoyl-4-(4-methoxybenzylthio)-1-ethylpyrrolidine

→

title compound

(2S, 4S)-2-Carbamoyl-4-(4-methoxybenzylthio)-1-ethyl-1-methylpyrrolidinium fluorosulfonate

溶媒

methylene chloride

反応条件

後処理

1. 1
   その他At the end of this time, the solvent was removed by distillation under reduced pressure
2. 2
   洗浄the residue was washed repeatedly by decantation with diethyl ether
3. 3
   その他dried under reduced pressure

実験手順

0.43 ml of methyl fluorosulfonate was added, whilst ice-cooling, to a solution of 1.44 g of (2S, 4S)-2-carbamoyl-4-(4-methoxybenzylthio)-1-ethylpyrrolidine dissolved in 30 ml of dry methylene chloride and the mixture was stirred at room temperature for 2 hours. At the end of this time, the solvent was removed by distillation under reduced pressure, and the residue was washed repeatedly by decantation with diethyl ether and dried under reduced pressure to afford 2.0 g of the title compound as an oil.

出典