反応 #5191

反応方程式

hydrochloric acid

sodium hydroxide

(2S, 4S)-4-(4-methoxybenzylthio)-2-methoxycarbonyl-1-methylpyrrolidine

→

(2S, 4S)-2-carboxy-4-(4-methoxybenzylthio)-1-methylpyrrolidine

収率 120.2%

溶媒

methanol

反応条件

後処理

1. 1
   その他the reaction mixture was freed from the solvent by evaporation under reduced pressure
2. 2
   その他the residue was dried
3. 3
   濃縮concentrated by evaporation under reduced pressure

実験手順

5.32 ml of a 1N aqueous solution of sodium hydroxide were added to a solution of 1.31 g of (2S, 4S)-4-(4-methoxybenzylthio)-2-methoxycarbonyl-1-methylpyrrolidine dissolved in 11 ml of methanol, and the mixture was stirred at room temperature for 2 hours. At the end of this time, it was neutralized with 5.32 ml of 1N aqueous hydrochloric acid, and the reaction mixture was freed from the solvent by evaporation under reduced pressure, and the residue was dried and concentrated by evaporation under reduced pressure, to afford 1.5 g of crude (2S, 4S)-2-carboxy-4-(4-methoxybenzylthio)-1-methylpyrrolidine.

出典