反応 #51890

反応方程式

3-trifluoromethyl 4-fluoro-benzonitrile

diethanolamine

→

3-trifluoromethyl-4-[bis(2-hydroxyethyl)amino]benzonitrile

溶媒

N,N-dimethylacetamide

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   その他the residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml)
3. 3
   乾燥the organic layer dried (MgSO4)
4. 4
   その他evaporated to dryness
5. 5
   その他The residue was chromatographed

実験手順

A solution of 3-trifluoromethyl 4-fluoro-benzonitrile (9.45 g, 50 mmol) and diethanolamine (15.8 g, 0.15 mol) in N,N-dimethylacetamide (200 ml) was stirred for 7 days at 50° C. The solvent was evaporated, the residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml), the organic layer dried (MgSO4) and evaporated to dryness. The residue was chromatographed using CH2Cl2-EtOH as eluent.

出典