反応 #5182

反応方程式

methyl fluorosulfonate

(2S, 4S)-2-(N,N-dimethylcarbamoyl)-4-(4-methoxybenzylthio)-1-methylpyrrolidine

→

title compound

(2S, 4S)-2-(N,N-Dimethylcarbamoyl)-4-(4-methoxybenzylthio)-1,1-dimethylpyrrolidinium fluorosulfonate

溶媒

methylene chloride

反応条件

後処理

1. 1
   workup.DISTILLATIONAt the end of this time, the solvent was distilled off under reduced pressure
2. 2
   洗浄The residue was repeatedly washed by decantation with hexane
3. 3
   その他dried under reduced pressure

実験手順

139 μl of methyl fluorosulfonate were added, whilst ice-cooling, to a solution of 190 mg of (2S, 4S)-2-(N,N-dimethylcarbamoyl)-4-(4-methoxybenzylthio)-1-methylpyrrolidine [prepared as described in step (5) or (11) above] dissolved in 3.8 ml of methylene chloride, and the mixture was stirred at room temperature for 2 hours. At the end of this time, the solvent was distilled off under reduced pressure. The residue was repeatedly washed by decantation with hexane and dried under reduced pressure, to give 356 mg of the title compound as an oil.

出典