反応 #51782

ord-33c8e64f93bf448d8862db834a1d0ff1

反応方程式

CC(C)C1(CCc2ccco2)CC(O)=CC(=O)O1
6-(2-furan-2-yl-ethyl)-4-hydroxy-6-isopropyl-5,6-dihydro-pyran-2-one
Cc1ccc(S(=O)(=O)Sc2cc(C)c(CO)cc2C(C)(C)C)cc1
toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl)ester
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
Cc1cc(SC2=C(O)CC(CCc3ccco3)(C(C)C)OC2=O)c(C(C)(C)C)cc1CO
title compound
Cc1cc(SC2=C(O)CC(CCc3ccco3)(C(C)C)OC2=O)c(C(C)(C)C)cc1CO
3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-6-(2-furan-2-yl-ethyl)-4-hydroxy-6-isopropyl-5,6-dihydro-pyran-2-one

反応物

CC(C)C1(CCc2ccco2)CC(O)=CC(=O)O1
6-(2-furan-2-yl-ethyl)-4-hydroxy-6-isopropyl-5,6-dihydro-pyran-2-one
Cc1ccc(S(=O)(=O)Sc2cc(C)c(CO)cc2C(C)(C)C)cc1
toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl)ester
O=C([O-])[O-].[K+].[K+]
potassium carbonate

試薬

なし

溶媒

CN(C)C=O
DMF

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compound was prepared as described in General Method 16a using 6-(2-furan-2-yl-ethyl)-4-hydroxy-6-isopropyl-5,6-dihydro-pyran-2-one (Example E-17; 1 mmol), toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl)ester (Example BB-2; 1.1 mmol), potassium carbonate (4 mmol) in DMF (5 mL) mp 64-110° C. MS (APCI): 457 (M−H).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06852711B2uspto-grants-2005_02