反応 #517675

反応方程式

N-(3-bromophenyl)-4,6-quinazolindiamine

trans-crotonoyl chloride

→

N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-(E)-2-butenamide

溶媒

pyridine

ether

反応条件

後処理

1. 1
   温度cooling for 2 hours
2. 2
   その他the solvents were removed at reduced pressure
3. 3
   workup.ADDITIONThe residue was treated with water
4. 4
   その他the resulting solid recrystallized from n-butanol

実験手順

A solution of 1.6 g of N-(3-bromophenyl)-4,6-quinazolindiamine in 15 ml of pyridine was cooled in an ice bath and a solution of 0.57 ml of trans-crotonoyl chloride in 6 ml of ether was added dropwise. After stirring and cooling for 2 hours, the solvents were removed at reduced pressure. The residue was treated with water and the resulting solid recrystallized from n-butanol to give 0.69 g of N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-(E)-2-butenamide: mp=153-160° C., mass spectrum (m/e): M+H 383, 385.

出典