反応 #51763

反応方程式

5-tert-butyl-2-nitro-phenylamine

ammonium thiocyanate

bromine

→

title compound

5-tert-Butyl-2-nitro-4-thiocyanato-phenylamine

溶媒

MeOH

反応条件

後処理

1. 1
   その他The crude reaction mixture
2. 2
   その他was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

実験手順

The title compound was prepared according to the General Method 13 using 5-tert-butyl-2-nitro-phenylamine (prepared in Example PP-2; 170 g, 876 mmol), ammonium thiocyanate (400 g, 5260 mmol), bromine (140 g, 876 mmol), and MeOH (500 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 252 (M+H).

出典