反応 #51762

反応方程式

bromine

5-isopropyl-2-nitro-phenylamine

sodium thiocyanate

sodium bromide

→

title compound

5-Isopropyl-2-nitro-4-thiocyanato-phenylamine

溶媒

MeOH

反応条件

後処理

1. 1
   その他The crude reaction mixture
2. 2
   その他was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

実験手順

The title compound was prepared according to General Method 13 using 5-isopropyl-2-nitro-phenylamine (prepared in Example PP-1; 5.4 g, 30 mmol), sodium thiocyanate (14.6 g, 180 mmol), sodium bromide (3.7 g, 35.99 mmol), bromine (5.75 g, 36.0 mmol), and MeOH (100 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 238 (M+H).

出典