反応 #516879

反応方程式

4-(2,3-epoxypropoxy)benzaldehyde

4-(2,3-epoxypropoxy)benzaldehyde

4-hydroxy benzaldehyde

epichlorohydrin

NaOH

18-crown-6-ether

potassium t-butoxide

→

styryl glycidyl ether

収率 70.0%

溶媒

tetrahydrofuran

dimethylsulfoxide

反応条件

後処理

1. 1
   workup.ADDITIONcontaining

実験手順

The application gives the manufacture of styryl glycidyl ether by first synthesizing 4-(2,3-epoxypropoxy)benzaldehyde from 4-hydroxy benzaldehyde and epichlorohydrin in the presence of NaOH, tetra-n-butyl ammonium iodide and dimethylsulfoxide. 4-(2,3-epoxypropoxy)benzaldehyde was then added to a dry tetrahydrofuran solution (0° C., argon atmosphere) containing suspended methyl-triphosphonium bromide, catalytic amounts of 18-crown-6-ether and potassium t-butoxide. From this mixture styryl glycidyl ether was then obtained in a yield of 70%.

出典