反応 #51658

反応方程式

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride

→

7-methoxy-3-methylsulfanyl-1H-indole

収率 87.5%

溶媒

DMSO

反応条件

後処理

1. 1
   その他placed under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask
2. 2
   その他The flask was placed on a steam bath
3. 3
   温度heated until the bubbling
4. 4
   温度the reaction mixture was cooled
5. 5
   その他partitioned between ether and water
6. 6
   その他The organic layer was dried
7. 7
   ろ過filtered
8. 8
   その他evaporated to dryness

実験手順

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride (0.742 g) prepared in the manner described in Step 1 above was dissolved in DMSO (3 ml) and placed under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask. The flask was placed on a steam bath and heated until the bubbling stopped. When no more starting material was present, the reaction mixture was cooled and partitioned between ether and water. The organic layer was dried and filtered and then evaporated to dryness to afford 7-methoxy-3-methylsulfanyl-1H-indole (0.514 g, 87.5%).

出典