反応 #51634

反応方程式

bromo(4-nitrophenyl)acetaldehyde

potassium thiocyanate

cyclohexylamine

→

desired compound

N-cyclohexyl-5-(4-nitrophenyl)-1,3-thiazol-2-amine

溶媒

methanol

反応条件

後処理

1. 1
   温度the mixture is heated
2. 2
   温度under reflux until completion of the reaction (5-12 hours)
3. 3
   ろ過is filtered off
4. 4
   洗浄washed with water
5. 5
   その他The crude material is purified by usual silica gel chromatography

実験手順

A solution of bromo(4-nitrophenyl)acetaldehyde and potassium thiocyanate (1.2 equivalents) in methanol is stirred at room temperature for 1 hour. The cyclohexylamine (1,05 equivalents) is added drop-wise and the mixture is heated under reflux until completion of the reaction (5-12 hours). After cooling to 0° C. the precipitate is filtered off and washed with water. The crude material is purified by usual silica gel chromatography to give the desired compound.

出典