反応 #515186

反応方程式

3,4-Dihydro-2H-pyran

2-bromobenzylalcohol

sodium bicarbonate

→

1-bromo-2-(tetrahydropyran-2-yloxymethyl)benzene

収率 99.3%

溶媒

methylene chloride

反応条件

後処理

1. 1
   workup.STIRRINGThe mixture was stirred at room temperature for 2 hours
2. 2
   抽出The resulting mixture was extracted with methylene chloride
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   その他Evaporation of the solvent

実験手順

Pyridinium p-toluenesulfonate (0.30 g) was added to a solution of 2-bromobenzylalcohol (25.00 g, 0.134 mol) in methylene chloride (100 ml), and the mixture was stirred at room temperature. 3,4-Dihydro-2H-pyran (16.86 g, 0.200 mol) was added thereto. The mixture was stirred at room temperature for 2 hours, and saturated aqueous sodium bicarbonate solution (200 ml) was added. The resulting mixture was extracted with methylene chloride and dried over anhydrous magnesium sulfate. Evaporation of the solvent gave the desired compound 1-bromo-2-(tetrahydropyran-2-yloxymethyl)benzene (36.00 g, 99.3%) as an oil.

出典