反応 #51478

反応方程式

2-chloro-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide

3-aminopropanol

→

2-[(3-hydroxypropyl)amino]-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide

収率 82.6%

溶媒

ethanol

反応条件

後処理

1. 1
   温度After heating
2. 2
   その他the reaction in an oil bath at 60° C. for 1 day
3. 3
   その他the reaction was partitioned with ethyl acetate and water
4. 4
   その他The organic layer was separated
5. 5
   洗浄washed with brine
6. 6
   乾燥dried (Na2SO4)
7. 7
   その他the solvent was removed in vacuo

実験手順

To 2-chloro-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide (0.45 g, 1.9 mmol) in ethanol (10 mL) was added 3-aminopropanol (0.72 mL, 9.4 mmol) (a compound of formula (Y9)). After heating the reaction in an oil bath at 60° C. for 1 day, the reaction was partitioned with ethyl acetate and water. The organic layer was separated, washed with brine, dried (Na2SO4), and the solvent was removed in vacuo to give 0.44 g of 2-[(3-hydroxypropyl)amino]-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide, a compound of formula (Y10).

出典