反応 #51477

反応方程式

homopiperonylamine hydrochloride

triethylamine

chloroacetyl chloride

→

2-chloro-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide

収率 74.5%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   その他the reaction was partitioned with 1 N HCl
2. 2
   その他The organic layer was separated
3. 3
   洗浄washed with aqueous bicarbonate
4. 4
   乾燥dried (Na2SO4)
5. 5
   その他the solvent was removed in vacuo

実験手順

To homopiperonylamine hydrochloride (2.14 g, 10.6 mmol) (a compound of formula (Y7)) in CH2Cl2 (20 mL) in an ice bath was added triethylamine (3.1 mL, 21 mmol) and chloroacetyl chloride (0.85 mL, 10 mmol) (a compound of formula (Y6)). After warming to ambient temperature and stirring for 16 hours, the reaction was partitioned with 1 N HCl. The organic layer was separated, washed with aqueous bicarbonate, dried (Na2SO4), and the solvent was removed in vacuo to give 1.8 g of 2-chloro-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide, a compound of formula (Y8).

出典