反応 #51462

反応方程式

piperonylamine

Isobutyl chloroformate

N-Boc sarcosine

N-methylmorpholine

→

N-Boc sarcosine piperonyl amide

収率 95.0%

溶媒

THF

反応条件

後処理

1. 1
   workup.WAITAfter thirty minutes
2. 2
   その他all volatiles were removed under reduced pressure

実験手順

Isobutyl chloroformate (226 μL, 1.73 mmol) was added to a solution of N-Boc sarcosine (1.73 mmol) and N-methylmorpholine (192 μL, 1.73 mmol) in THF. After two minutes, piperonylamine (216 mL, 1.73 mmol) was added and the mixture allowed to warm to room temperature. After thirty minutes, the reaction mixture was passed through a bed of Celite and all volatiles were removed under reduced pressure to yield N-Boc sarcosine piperonyl amide (531 mg, 95%) as a white solid. 1H NMR: (CDCl3) δ2.41 (s,3), 3.28 (s,2), 4.39 (d,2), 5.95 (s,2), 6.80 (m,3), 7.43 (bs,1), 9.04 (bs,1).

出典