反応 #514566

反応方程式

N-Boc-hydroxyproline

tert-butylamine

HOBt

EDC hydrochloride

→

title compound

収率 189.0%

Boc-Hyp-NH-tBu

収率 189.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   workup.ADDITIONwere added under ice cooling
2. 2
   workup.ADDITIONThe reaction mixture was treated similarly to that in Example 144 (Process 2)

実験手順

In a dichloromethane solution containing 5.1 g of N-Boc-hydroxyproline (Boc-Hyp-OH), 0.35 g of tert-butylamine, 7.4 g of HOBt and 6.0 g of EDC hydrochloride were added under ice cooling and the resultant mixture was stirred overnight at room temperature. The reaction mixture was treated similarly to that in Example 144 (Process 2) to give 2.59 g of the title compound.

出典