反応 #51424

反応方程式

water

4-Nitro-1H-pyrrole-2-carboxylic acid ethyl ester

sodium ethoxide

1-bromo-3-methylbutane

→

product

収率 29.0%

1-(3-Methyl-butyl)-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester

収率 29.0%

溶媒

ethanol

ethanol

反応条件

後処理

1. 1
   workup.STIRRINGThe mixture was stirred
2. 2
   温度at reflux for 6 h
3. 3
   温度cooled to room temperature
4. 4
   その他The pale yellow precipitates
5. 5
   ろ過were collected by filtration
6. 6
   洗浄washed with water
7. 7
   その他dried

実験手順

4-Nitro-1H-pyrrole-2-carboxylic acid ethyl ester (3.69 g, 20.04 mmol) was dissolved in 100 ml of hot anhydrous ethanol and the solution was cooled to room temperature. 30 ml of sodium ethoxide (about 1M) in ethanol was added. The reaction mixture was stirred at room temperature for 20 min and 1-bromo-3-methylbutane (8 ml) was added. The mixture was stirred at reflux for 6 h and cooled to room temperature and then poured into water. The pale yellow precipitates were collected by filtration, washed with water, and dried to give the product (1.48 g, 29%).

出典