反応 #51412

反応方程式

CH2Cl2

1-iodo-2-methylpropane

5-(N-Boc-amino)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one

Cs2CO3

→

5-amino-7-(2-methylpropyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one Hydrochloride

溶媒

DMF

反応条件

後処理

1. 1
   温度After cooling to 23° C. the mixture
2. 2
   洗浄washed with several portions of brine
3. 3
   乾燥dried over Na2SO4
4. 4
   その他The title compound was purified by chromatography (SiO2, CHCl3/MeOH 9:1)

実験手順

A solution of 5-(N-Boc-amino)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one (0.2 g, 0.617 mmol) (Example 7-E) in DMF was treated with Cs2CO3 (0.22 g, 0.678 mmol) and warmed to 60° C. To the reaction mixture was added 1-iodo-2-methylpropane (0.078 ml, 0.678 mmol) and stirring continued for 17 h. After cooling to 23° C. the mixture was diluted with CH2Cl2, washed with several portions of brine and dried over Na2SO4. The title compound was purified by chromatography (SiO2, CHCl3/MeOH 9:1).

出典