反応 #51386

ord-37729bb4c6894c8b993186f8256bc5ed

反応方程式

O=C(O)Cc1cccc([N+](=O)[O-])c1
3-nitrophenylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride
→
CC(C)COC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1
title compound
CC(C)COC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1
N-[(3-nitrophenyl)acetyl]-L-alanine iso-butyl ester

反応物

O=C(O)Cc1cccc([N+](=O)[O-])c1
3-nitrophenylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他The reaction was monitored by tlc on silica gel and purification
  2. 2
    その他was by recrystallization from butyl chloride

実験手順

Following General Procedure BH above and using 3-nitrophenylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by recrystallization from butyl chloride.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06849650B2uspto-grants-2005_02