反応 #5135

ord-4b945c0b929b49f888af2cd922c9349b

反応方程式

COC(=O)c1ccc2c(c1)C(O)c1ccccc1CO2
Compound b
COC(=O)c1ccc2c(c1)C(O)c1ccccc1CO2
Methyl 11-hydroxy-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate
O.O.O=S([O-])c1ccccc1.[Na+]
sodium benzenesulfinate dihydrate
O=C(OC(=O)C(F)(F)F)C(F)(F)F
trifluoroacetic anhydride
→
COC(=O)c1ccc2c(c1)C(S(=O)(=O)c1ccccc1)c1ccccc1CO2
objective compound
COC(=O)c1ccc2c(c1)C(S(=O)(=O)c1ccccc1)c1ccccc1CO2
Methyl 11-phenylsulfonyl-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate

反応物

COC(=O)c1ccc2c(c1)C(O)c1ccccc1CO2
Compound b
COC(=O)c1ccc2c(c1)C(O)c1ccccc1CO2
Methyl 11-hydroxy-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate
O.O.O=S([O-])c1ccccc1.[Na+]
sodium benzenesulfinate dihydrate
O=C(OC(=O)C(F)(F)F)C(F)(F)F
trifluoroacetic anhydride

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Compound b, 10 g, 15 g of sodium benzenesulfinate dihydrate and 25 ml of trifluoroacetic anhydride were treated in a manner similar to Example 109 to give 14.3 g of the objective compound.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05242931uspto-grants-1993_09