反応 #51338

反応方程式

L-alanine

thionyl chloride

isobutanol

→

L-alanine iso-butyl ester hydrochloride

反応条件

後処理

1. 1
   その他the volatiles were removed completely on a rotavapor of 90° C. under reduced pressure

実験手順

A mixture of 35.64 g (0.4 mol) of (D,L)-alanine (Aldrich) (or L-alanine (Aldrich)); 44 mL (0.6 mol) of thionyl chloride (Aldrich) and 200 mL of isobutanol was refluxed for 1.5 hours and the volatiles were removed completely on a rotavapor of 90° C. under reduced pressure to give (D,L)-alanine iso-butyl ester hydrochloride (or L-alanine iso-butyl ester hydrochloride), which was pure enough to be used for further transformations.

出典