反応 #51294

反応方程式

3,5-difluorophenylacetic acid

(S)-2-(1-aminoethyl)-5(R,S)-ethoxycarbonyl-2-oxazoline

→

title compound

(S)-2-[1-(3,5-difluorophenylacetamido)ethyl]-5(R,S)-ethoxycarbonyl-2-oxazoline

溶媒

MeOH CHCl3

反応条件

後処理

1. 1
   その他the product was purified by silica gel chromatography

実験手順

Following General Procedure A and using 3,5-difluorophenylacetic acid (Aldrich) and (S)-2-(1-aminoethyl)-5(R,S)-ethoxycarbonyl-2-oxazoline (Example F), the title compound was prepared as a semisolid. The reaction was monitored by tlc (Rf=0.3 in 5% MeOH/CHCl3) and the product was purified by silica gel chromatography using 5% MeOH/CHCl3 as the eluent.

出典