反応 #51284

反応方程式

3,5-Difluorophenylacetic acid

DMF

oxalyl chloride

→

3,5-difluorophenylacetyl chloride

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他to give an oil which

実験手順

3,5-Difluorophenylacetic acid (30 g, 0.174 mol) (Aldrich) was dissolved in dichloromethane and this solution was cooled to 0° C. DMF (0.5 mL. catalytic) was added followed by the dropwise addition of oxalyl chloride (18 mL. 0.20 mol) over a 5 minute period. The reaction was stirred for 3 h and then rotoevaporated at reduced pressure to give an oil which was placed on a high vacuum pump for1 h to afford 3,5-difluorophenylacetyl chloride as a thin yellow oil. Other acid chlorides can be prepared in a similar manner.

出典