反応 #51276

反応方程式

4-bromophenol

isobutylene

→

2-tert-butyl-4-bromophenol

反応条件

後処理

1. 1
   その他is passed through for 30 hours
2. 2
   温度The reaction mixture is cooled
3. 3
   その他the residue is purified
4. 4
   洗浄eluted with a mixture
5. 5
   その他88.00 g (90%) of the expected compound are collected in the form of a yellow oil

実験手順

80.00 g (426.0 mmol) of 4-bromophenol and 8.00 g of Dowex 50WX8 sulphonic acid resin are mixed in a 250 ml three-necked flask. The mixture is heated to 80° C. and a stream of isobutylene is passed through for 30 hours. The reaction mixture is cooled and the residue is purified by passing through a silica column eluted with a mixture composed of 95% dichloromethane and of 5% heptane. 88.00 g (90%) of the expected compound are collected in the form of a yellow oil.

出典