反応 #51163

反応方程式

2-chloro-6-methoxy-3-nitropyridine

sodium thiomethoxide

→

6-methoxy-2-methylthio-3-nitropyridine

収率 60.5%

溶媒

methanol

methanol

反応条件

後処理

1. 1
   温度while being cooled with ice
2. 2
   ろ過the precipitated crystal was filtered

実験手順

A methanol (100 ml) solution of 2-chloro-6-methoxy-3-nitropyridine (2.0 g, 10.4 mmol) was added dropwise to a methanol (20 ml) solution of sodium thiomethoxide (805 mg, 10.9 mmol) while being cooled with ice, and the temperature thereof was raised to the room temperature and the mixed solution was stirred for 17 hours and the precipitated crystal was filtered to obtain 1.26 g (yield 59%) of 6-methoxy-2-methylthio-3-nitropyridine as a yellow powdery crystal.

出典