反応 #511531

ord-c496759c39674951a78b842a9f5b02a2

反応方程式

CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)ON1C(=O)CCC1=O
Boc-Phe-OSu
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
oxycodone
[Li][N]([Si](C)(C)C)[Si](C)(C)C
LiN(TMS)2
→
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.N[C@@H](Cc1ccccc1)C(=O)O
Phe Oxycodone

反応物

CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)ON1C(=O)CCC1=O
Boc-Phe-OSu
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
oxycodone
[Li][N]([Si](C)(C)C)[Si](C)(C)C
LiN(TMS)2

試薬

なし

溶媒

C1CCOC1
tetrahydrofuran

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他quenched with water and solvents
  2. 2
    その他removed
  3. 3
    その他was purified

実験手順

To a solution of oxycodone-freebase (1.0 eq) in tetrahydrofuran (THF) (10 ml/mmol) was added LiN(TMS)2 (3.5 eq). After 5 minutes, Boc-Phe-OSu (3.5 eq) was added. The reaction was stirred at ambient temperatures for 18 hours, quenched with water and solvents removed. Crude protected product was purified using reverse-phase HPLC. Deprotection occurred with 4N HCl in dioxane (20 ml/mmol) to obtain Phe-Oxycodone.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08106016B2uspto-grants-2012_01