反応 #510436

反応方程式

sodium hydroxide

4-benzyloxybenzonitrile

sodium azide

ammonium chloride

→

title compound

収率 95.0%

5-(4-Benzyloxyphenyl)-2H-tetrazole

収率 95.0%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度under heating
2. 2
   温度for cooling to room temperature
3. 3
   洗浄by washing with diethyl ether
4. 4
   workup.ADDITIONTo the aqueous layer was added 1N hydrochloric acid
5. 5
   その他the resulting precipitated solid
6. 6
   ろ過was filtered

実験手順

To a solution of 4-benzyloxybenzonitrile (2.0 g) in dimethylformamide (15 mL) were added sodium azide (932 mg) and ammonium chloride (767 mg). The mixture was stirred at 110° C. overnight under heating and then allowed to stand for cooling to room temperature. 1N aqueous sodium hydroxide was added thereto to adjust the pH to about 10, followed by washing with diethyl ether. To the aqueous layer was added 1N hydrochloric acid, and the resulting precipitated solid was filtered to give the title compound (2.29 g).

出典