反応 #5102

反応方程式

p-tert-butylphenol

sodium hydride

butyl acrylate

→

butyl 3-(p-tert-butylphenoxy)-propionate

収率 45.2%

反応条件

後処理

1. 1
   その他was then reduced to 100° C.
2. 2
   workup.DISTILLATIONthe excess acrylate distilled under gentle vacuum
3. 3
   ろ過The resulting oil was filtered through 900 g silica gel (90 to 200 mesh)

実験手順

A solution of 25 g (0.167 mole) p-tert-butylphenol, 0.2 g sodium hydride (as 50% dispersion in oil), 0.2 g N-phenyl-2-naphthylamine (as basic polymerization inhibitor) in 75.0 g (0.586 mole) butyl acrylate was heated at 125° C. for four hours. The temperature was then reduced to 100° C. and the excess acrylate distilled under gentle vacuum. The resulting oil was filtered through 900 g silica gel (90 to 200 mesh) using chloroform as eluant to yield 21.0 g pure butyl 3-(p-tert-butylphenoxy)-propionate (45%).

出典