反応 #51010

反応方程式

3-methoxy-6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-pyridazine

HCl

→

desired product

6-(5-Chloro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin 2H-pyridazin-3-one

溶媒

dioxane

反応条件

後処理

1. 1
   温度The reaction mixture was cooled
2. 2
   その他evaporated to dryness
3. 3
   workup.ADDITIONWater (20 mL) was added to the residue
4. 4
   その他The resulting precipitate was collected
5. 5
   その他crystallized from ethanol

実験手順

A mixture of 3-methoxy-6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-pyridazine (22.2 mmol, 7.5 g), conc. HCl (5 mL), and dioxane (50 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. Water (20 mL) was added to the residue. The resulting precipitate was collected and crystallized from ethanol to obtain the desired product: 6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin-2H-pyridazin-3-one (89%, 6.42 g).

出典