反応 #5089

反応方程式

hydrochloric acid

2'-methoxy-5'-methylpropiophenone

benzaldehyde

sodium hydroxide

→

2'-methoxy-5'-methyl-2-benzylidenepropiophenone

収率 101.3%

溶媒

ethanol

反応条件

後処理

1. 1
   workup.STIRRINGThe reaction mixture was stirred overnight at room temperature
2. 2
   抽出extracted with benzene
3. 3
   抽出The benzene extract
4. 4
   洗浄was washed with water
5. 5
   乾燥an aqueous solution saturated with sodium chloride in this order, then dried

実験手順

To a mixture of 140 g of 2'-methoxy-5'-methylpropiophenone, 83.4 g of benzaldehyde and 1.5 liters of ethanol was added 154 ml of 20%-sodium hydroxide aqueous solution under stirring. The reaction mixture was stirred overnight at room temperature, then 10%-hydrochloric acid was added to make the reaction mixture acidic, and extracted with benzene. The benzene extract was washed with water and an aqueous solution saturated with sodium chloride in this order, then dried to obtain 212 g of 2'-methoxy-5'-methyl-2-benzylidenepropiophenone. Yellow oily substance.

出典