反応 #50849

反応方程式

1-(p-N-tert-butylaminocarbonylphenyl)-4-(1-trityl-4-imidazolyl)-1-butanone

→

1-(p-cyanophenyl)-4-(4-imidazolyl)-1-butanone

溶媒

thionyl chloride

反応条件

後処理

1. 1
   抽出The aqueous phase is extracted with ether (3×20 ml)
2. 2
   その他The organic phase is dried
3. 3
   その他evaporated

実験手順

A solution of 0.5 g of 1-(p-N-tert-butylaminocarbonylphenyl)-4-(1-trityl-4-imidazolyl)-1-butanone in 20 ml of thionyl chloride is refluxed for 3 h and poured into 100 ml of ice-water. The aqueous phase is extracted with ether (3×20 ml), adjusted to pH=10 and reextracted with methylene chloride. The organic phase is dried and evaporated to yield 1-(p-cyanophenyl)-4-(4-imidazolyl)-1-butanone.

出典