反応 #50847

反応方程式

hydrochloric acid

1-(p-cyanophenyl)-4-(4-imidazolyl)-1-butanone

sodium cyanoborohydride

→

5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

溶媒

methanol

反応条件

後処理

1. 1
   その他evaporated to dryness
2. 2
   洗浄washed with saturated sodium bicarbonate
3. 3
   乾燥The organic layer is dried over sodium sulfate
4. 4
   その他evaporated

実験手順

A solution of 0.24 g of 1-(p-cyanophenyl)-4-(4-imidazolyl)-1-butanone in 20 ml of methanol at room temperature is treated with 0.2 g of sodium cyanoborohydride. The pH is adjusted and maintained at 5.5-6.0 by addition of concentrated hydrochloric acid. The reaction mixture is stirred for 2 h, adjusted to pH 2, and evaporated to dryness. The residue is taken up in methylene chloride and washed with saturated sodium bicarbonate. The organic layer is dried over sodium sulfate and evaporated to yield 5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine.

出典