反応 #50846

反応方程式

5-(p-cyanophenyl)-3-ethoxycarbonyl-imidazo[1,5-a]pyridine

→

5-(p-cyanophenyl)-3-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   その他evaporated to dryness
3. 3
   その他The resulting oil is partitioned between water and ethyl acetate
4. 4
   その他The organic phase is separated
5. 5
   乾燥dried over sodium sulfate
6. 6
   その他evaporated
7. 7
   その他The residue is chromatographed on 40 g of silica gel with ethyl acetate

実験手順

A solution of 1.1 g of 5-(p-cyanophenyl)-3-ethoxycarbonyl-imidazo[1,5-a]pyridine in 30 ml of ethanol is hydrogenated with 0.1 g of 10% Pd on charcoal at 1 bar for 2 h, filtered and evaporated to dryness. The resulting oil is partitioned between water and ethyl acetate. The organic phase is separated, dried over sodium sulfate and evaporated. The residue is chromatographed on 40 g of silica gel with ethyl acetate to yield 5-(p-cyanophenyl)-3-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine.

出典