反応 #50833

反応方程式

hydrochloric acid

5-(p-cyanophenyl)-5-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

sodium hydroxide

→

title compound

5-(p-Cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

溶媒

methanol

反応条件

後処理

1. 1
   温度The reaction mixture is refluxed for 1 h
2. 2
   温度cooled
3. 3
   その他evaporated
4. 4
   その他The residue is partitioned between water and ethyl acetate
5. 5
   その他The organic layer is separated
6. 6
   乾燥dried over sodium sulfate
7. 7
   その他evaporated

実験手順

A solution of 1.65 g of 5-(p-cyanophenyl)-5-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine in 10 ml of methanol containing 0.2 g of sodium hydroxide is stirred for 3 h at room temperature and 5 ml of 1N hydrochloric acid is added. The reaction mixture is refluxed for 1 h, cooled and evaporated. The residue is partitioned between water and ethyl acetate. The organic layer is separated, dried over sodium sulfate and evaporated to yield the title compound.

出典