反応 #50829

反応方程式

5-(p-formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

hydrazoic acid

sulfuric acid

→

title compound

5-(p-Cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

溶媒

benzene

反応条件

後処理

1. 1
   workup.ADDITIONis added dropwise
2. 2
   その他The organic phase is separated
3. 3
   乾燥dried over sodium sulfate
4. 4
   その他evaporated
5. 5
   その他to yield an oil which
6. 6
   その他is chromatographed on silica gel with ethyl acetate

実験手順

A solution of 2.01 g of 5-(p-formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 0.96 g of hydrazoic acid in 30 ml benzene is maintained by external cooling at room temperature, while 0.8 ml of concentrated sulfuric acid is added dropwise. The reaction mixture is stirred for 2 h and neutralized. The organic phase is separated, dried over sodium sulfate and evaporated to yield an oil which is chromatographed on silica gel with ethyl acetate to yield the title compound.

出典